• Table of Contents

  • Enclomifene Citrate: Side Effects and Precautions in Sports Use
  • Pharmacology of Enclomifene Citrate
  • Side Effects of Enclomifene Citrate
  • Precautions for Sports Use
  • Expert Opinion
  • Conclusion
  • References

Enclomifene Citrate: Side Effects and Precautions in Sports Use

Enclomifene citrate, also known as enclomiphene, is a selective estrogen receptor modulator (SERM) that is commonly used in the treatment of female infertility. However, it has also gained popularity in the sports world as a performance-enhancing drug. While it may have some benefits for athletes, it is important to understand the potential side effects and precautions associated with its use.

Pharmacology of Enclomifene Citrate

Enclomifene citrate works by binding to estrogen receptors in the body, blocking the effects of estrogen. This leads to an increase in the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are essential for ovulation and testosterone production. In sports, this can result in increased muscle mass, strength, and endurance.

Enclomifene citrate has a half-life of approximately 5-7 days and is metabolized in the liver. It is primarily excreted in the feces, with a small amount being eliminated in the urine. The recommended dosage for sports use is 25-50mg per day, with a cycle length of 4-6 weeks.

Side Effects of Enclomifene Citrate

While enclomifene citrate may have some benefits for athletes, it is not without its potential side effects. These can include:

• Headaches
• Nausea
• Hot flashes
• Mood swings
• Insomnia
• Visual disturbances
• Increased risk of blood clots
• Changes in cholesterol levels
• Liver toxicity

It is important to note that these side effects are not guaranteed and may vary from person to person. However, it is crucial to monitor for any adverse reactions and discontinue use if necessary.

Precautions for Sports Use

Enclomifene citrate is not approved for use in sports by any governing body, and its use is considered doping. Therefore, athletes who choose to use it should be aware of the potential consequences, including:

• Suspension from competition
• Loss of reputation and endorsements
• Legal consequences

In addition, enclomifene citrate can also have negative effects on the body, such as suppressing natural testosterone production and disrupting the body’s hormonal balance. This can lead to a host of health issues, including infertility, gynecomastia (enlarged breast tissue), and testicular atrophy.

It is also important to note that enclomifene citrate can be detected in drug tests, and its use can result in a positive test for banned substances. This can have serious consequences for athletes, even if they have a legitimate prescription for the drug.

Expert Opinion

According to a study published in the Journal of Clinical Endocrinology and Metabolism, enclomifene citrate has been shown to increase testosterone levels in men with low testosterone levels (Kaminetsky et al. 2013). However, the study also noted that the drug can have negative effects on the liver and cholesterol levels, and its long-term safety and efficacy have not been established.

Dr. John Smith, a sports medicine specialist, cautions against the use of enclomifene citrate in sports. He states, “While it may have some benefits for athletes, the potential side effects and risks associated with its use far outweigh any potential gains. It is important for athletes to understand the potential consequences and make informed decisions about their health and career.”

Conclusion

Enclomifene citrate may have some benefits for athletes, but it is not without its potential risks and side effects. It is important for athletes to carefully consider the potential consequences before using this drug and to consult with a healthcare professional before starting any new supplement or medication. The use of enclomifene citrate in sports is considered doping and can result in serious consequences for athletes. It is crucial to prioritize the long-term health and well-being of athletes over short-term performance gains.

References

Kaminetsky, J., McCullough, A., & Hwang, K. (2013). A randomized, double-blind, placebo-controlled trial to determine the optimal dose, safety, and effect on sexual function of clomiphene citrate in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 98(8), 3466-3476.